“There’s more than one way to skin a cat” is a weirdly morbid saying, but the phrase’s core concept rings true – there are a lot of ways to accomplish the same task. This has never been more true for cannabidiol (CBD). With the rising demand for CBD products, there are a plethora of different ways to get your daily dose. They range from sublingual sprays, to vaping CBD oils, to smoking good old-fashioned joints. Yet most people don’t know that the way in which you ingest CBD can drastically alter its effective dosage.
In general, not all of the CBD you consume will directly affect your body: only a certain percentage will be able to enter your systemic circulation and produce its active effects. This percentage is referred to in science as “bioavailability,” and it strongly depends on the manner in which CBD is introduced to your system. For example, the oral bioavailability of CBD is roughly 15 percent. That means for every 100 milligrams of CBD that you eat, only 15 milligrams will actually reach your bloodstream.
There are two main reasons why this happens. First, CBD is hydrophobic, meaning that it is not very water-soluble. In the same way that oil does not like to mix with vinegar, CBD does not like to stay in your bloodstream. Instead, it rapidly diffuses out of your blood and accumulates into your fatty tissues. Unfortunately, this significantly reduces the amount of bioactive CBD that can enter your systemic circulation, allowing for less CBD to be carried to its active sites in your body and thus lowering its overall bioavailability.
Second, when an organic compound like CBD enters your gut, it has to pass through the liver before it enters your circulation. During this transition, the liver will actively reduce the amount of CBD, either through absorption or through chemical breakdown by liver enzymes. This phenomenon is called the “first-pass effect,” where passing through the liver reduces the concentration of bioactive compounds.
There are a few different ways to offset these losses of CBD. For one, you can reduce the amount of CBD that dissolves out of your bloodstream by putting the CBD into a form that is more hydrophilic, or water-soluble. However, this can only be achieved by complicated chemical means, such as through the use of cyclodextrins or liposomes. A more practical solution is to bypass the first-pass effect of oral administration entirely by utilizing vaporization.
During vaporization, CBD enters your lungs and diffuses directly into your bloodstream rather than passing through your gut and liver. This avoids the first-pass effect altogether, allowing nearly four times as much CBD to enter your circulation for a maximum bioavailability of roughly 50 to 60 percent. Essentially, this means you can achieve the same beneficial effects with a much smaller amount of CBD.
Not only that, but vaping will greatly decrease the amount of time it takes for the CBD in your body to become active, since you don’t have to wait for it to travel through your gut. By vaporizing a CBD e-liquid or high-CBDconcentrate, you could potentially feel its effects 30 to 60 minutes faster. This makes vaping CBD an extremely efficient delivery method.
CBD isn’t just great for physical afflictions. It’s great treatment for mental afflictions as well. Social anxiety disorder is a prime candidate for treatment because the CBD in marijuana decreases activity in the limbic system. It also plays a large role in the formation of memories. Emotional life is largely housed in the limbic system which supports epinephrine flow, emotions, behavior, motivation, long-term memory, and olfaction. Anonymous Colorado grower and dispensary owner Johnny Hempseed has tried CBD oil for social anxiety and agrees that it is great for people who want therapeutic benefits of traditional cannabis.
The human body has an endocannabinoid system (ECS) that receives and translates signals it receives from cannabinoids in the body. The body produces some cannabinoids on its own, which are called endocannabinoids. The ECS helps regulate functions such as sleep, immune-system responses, and pain.
THC produces a "high" feeling by affecting the brain's endocannabinoid receptors. This activates the brain's reward system, producing pleasure chemicals such as dopamine.
CBD is an entirely different compound, and its effects are very complex. It is not psychoactive, meaning it does not produce a "high" or change a person's state of mind. Instead, it influences the body to use its own endocannabinoids more effectively.
A study in the European Journal of Pain used an animal model to see if CBD could help people with arthritis manage their pain. Researchers applied a topical gel containing CBD to rats with arthritis for 4 days.
Their research noted a significant drop in inflammation and signs of pain, without additional side effects.
People using CBD oil for arthritis may find relief from their pain, but more human studies need to be done to confirm these findings.
Multiple sclerosis (MS) is an autoimmune disease that affects the entire body through the nerves and brain.
Muscle spasms are one of the most common symptoms of MS. These spasms can be so great they cause constant pain in some people.
One report found that short-term use of CBD oil could reduce the levels of spasticity a person feels. The results are modest, but many people reported a reduction in symptoms. More human studies are needed to verify these results.
The same report studied CBD use for general chronic pain. Researchers compiled the results of multiple systematic reviews covering dozens of trials and studies. Their research concluded that there is substantial evidence that cannabis is an effective treatment for chronic pain in adults.
A separate study in the Journal of Experimental Medicine supports these results. The research suggests pain and inflammation can be reduced through CBD use.
They also found that subjects were not likely to build up a tolerance to the effects of CBD, so they would not need to continually increase their dose. Researchers noted cannabinoids such as CBD could be a helpful new treatment for people with chronic pain.
Some people may find that using CBD for anxiety makes them too sleepy, sedated, or detached. Others may appreciate this effect because it helps them sleep and get a better rest. If CBD makes you sleepy, you may want to only use it at night.
The exact mechanism by which CBD helps with anxiety and depression is still under investigation. Based on the current evidence available, researchers believe that CBD’s antianxiety effects are a result of its action on the 5-HT1A receptors of the serotonergic system.
CBD’s effect on anxiety may also be due to its impact on a poorly functioning endocannabinoid system. By supplementing with CBD, users may be helping their endocannabinoid system work better because CBD helps increase levels of endocannabinoids in the body.
CBD oil comes from industrial hemp —it’s something you hear repeated constantly. Everything we make starts with industrial hemp.
That’s because unlike THC, which comes from cannabis, CBD is a non-psychoactive legal alternative that may bring you much-needed relief.
Our CBD oil also uses industrial hemp because we want to add high-quality cannabinoids to our products without causing any ill effects, and all-natural CBD from industrial hemp is the best way to do just that.
Industrial hemp is different from cannabis. It grows slightly larger leaves and stands with a skinnier stalk. And it only has 0.03 percent THC, nowhere near enough to cause any trouble. Industrial hemp is around 40 percent cannabidiol, which makes it a key ingredient in all CBD oils.
Hemp is considered a low maintenance plant because it doesn’t require much “babysitting.” It uses less water and can fight off bugs without pesticides. Industrial hemp grows quickly, too —in three months, which makes it a favorite among small farmers and CBD oil manufacturers.
Industrial hemp’s low-maintenance attitude makes it very malleable for different industries. That’s why it’s called “industrial.” It’s used in textiles, construction, animal feed, even paper. One acre of hemp can yield 1300 pounds of fiber, 530 pounds of feed, or 22 gallons of oil.
Hemp is predominantly CBD, and industrial hemp can be bred to contain even higher levels of the cannabinoid for our CBD oil if we want. Many countries, including the United States, federally require hemp to have less than .03% THC. But there are no limits to the levels of CBD.
Today’s technology makes it possible to distinguish between THC and CBD levels. Companies can control how much CBD is in their CBD oil and limit the amount of THC. That’s how we create our CBD Vape Liquid. Our ingredients come from 100 percent all natural industrial hemp so you can vape with confidence.
You knew the answer to this one —absolutely. CBD oil that comes from industrial hemp, as per the Farm Bill of 2014 is perfectly legal in the United States.
Our CBD oils use premium industrial hemp because it’s legal. To sell our oils and edibles online, we guarantee that our industrial hemp products don’t contain more than .03 percent THC.
We want to protect our customers’ health and legal well-being, so we use industrial hemp in all of our CBD vape liquids.
If you are new to CBD oil and want to give it a try, go for our Strawberry flavored liquid —you won’t be disappointed. These treats are a great way to introduce your body to the health benefits of CBD oil.